Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 7/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200714 | 1.00 | CDK1 (0.44) | CDK1ERN1NT5EDRD2DRD3 | |
| SCHEMBL27695212 | 0.80 | DRD2 (0.40) | DRD2DRD3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5184704 | 0.80 | DRD2 (0.40) | DRD2DRD3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6834244 | 0.78 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3ADRB2HTR1A | |
| SCHEMBL1929978 | 0.77 | DRD2 (0.40) | DRD2DRD3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1551829 | 0.76 | DRD2 (0.42) | DRD2DRD3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27828941 | 0.76 | DRD2 (0.42) | DRD2DRD3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21249083 | 0.75 | DRD2 (0.56) | DRD2DRD3SLC6A3HTR1AESR2 | |
| SCHEMBL27537852 | 0.74 | DRD2 (0.55) | DRD2DRD3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16759290 | 0.74 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844026-A2 | MORPHOLINES AS 5HT2C AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006077025-A2 | MORPHOLINES AS 5HT2C AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-27 | — | — | WO | disclosed |