Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.57 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202638 | 0.92 | KMT2A (0.62) | KMT2ANR1H4SMPD1KAT6ALMNA | |
| SCHEMBL8465014 | 0.90 | SMPD1 (0.68) | KMT2ANR1H4SMPD1TSHRPLA2G4B | |
| SCHEMBL9906433 | 0.89 | SMPD1 (0.70) | KMT2ANR1H4SMPD1TSHRPLA2G4B | |
| SCHEMBL9305977 | 0.89 | SMPD1 (0.70) | KMT2ANR1H4SMPD1TSHRPLA2G4B | |
| SCHEMBL15779400 | 0.89 | SMPD1 (0.70) | KMT2ANR1H4SMPD1TSHRPLA2G4B | |
| SCHEMBL5204104 | 0.89 | SMPD1 (0.70) | KMT2ANR1H4SMPD1TSHRPLA2G4B | |
| SCHEMBL11337002 | 0.89 | SMPD1 (0.70) | KMT2ANR1H4SMPD1TSHRPLA2G4B | |
| SCHEMBL1331352 | 0.89 | SMPD1 (0.70) | KMT2ANR1H4SMPD1TSHRPLA2G4B | |
| SCHEMBL11422303 | 0.86 | PRSS1 (0.60) | KMT2ASMPD1PLA2G4BTHRATHRB | |
| SCHEMBL27913517 | 0.86 | KMT2A (0.78) | KMT2ANR1H4SMPD1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117304205-A | Benzimidazole ternary fused ring compound, pharmaceutically acceptable salt thereof and application thereof | 中国科学院广州生物医药与健康研究院 | 2023-12-29 | — | — | CN | disclosed |
| EP-1087946-B1 | ARYL ALKANOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2007-01-10 | — | — | EP | disclosed |
| CN-1168720-C | Aryl alkanoylpyridazines | Ĭ��ר���ɷ�����˾ | 2004-09-29 | — | — | CN | disclosed |
| US-6417188-B1 | ENZYME INHIBITORS OF PHOSPHODIESTERASE | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-07-09 | — | — | US | disclosed |
| CN-1305465-A | Aryl alkanoylpyridazines | MERCK PATENT GMBH (DE) | 2001-07-25 | — | — | CN | disclosed |
| EP-1087946-A1 | ARYL ALKANOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065880-A1 | ARYL ALKANOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 1999-12-23 | — | — | WO | disclosed |
| US-4001426-A | HAVING CORONARY VASODILATOR ACTIVITY | SMITHKLINE CORPORATION (US) | 1977-01-04 | — | — | US | disclosed |