Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.58 |
| ▸ | INSR | P06213 | 3/20 | 0.58 |
| ▸ | LYN | P07948 | 3/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.58 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.58 |
| ▸ | FLT4 | P35916 | 3/20 | 0.58 |
| ▸ | FLT3 | P36888 | 3/20 | 0.58 |
| ▸ | STK3 | Q13188 | 3/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.58 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.58 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.58 |
| ▸ | RET | P07949 | 2/20 | 0.58 |
| ▸ | FRK | P42685 | 2/20 | 0.58 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.58 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.58 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3298032 | 0.91 | IGF1R (0.68) | IGF1RROCK2INSRLYNFGFR1 | |
| SCHEMBL3298049 | 0.90 | IGF1R (0.69) | IGF1RROCK2INSRLYNFGFR1 | |
| SCHEMBL3294619 | 0.88 | IGF1R (0.69) | IGF1RROCK2INSRLYNFGFR1 | |
| SCHEMBL3297994 | 0.86 | IGF1R (0.75) | IGF1RROCK2INSRLYNFGFR1 | |
| SCHEMBL3301850 | 0.85 | IGF1R (0.76) | IGF1RROCK2INSRLYNFGFR1 | |
| SCHEMBL3294653 | 0.85 | IGF1R (0.76) | IGF1RROCK2INSRLYNFGFR1 | |
| SCHEMBL3298071 | 0.83 | IGF1R (0.76) | IGF1RROCK2INSRLYNFGFR1 | |
| SCHEMBL3303492 | 0.82 | IGF1R (0.73) | IGF1RROCK2INSRLYNFGFR1 | |
| SCHEMBL5216744 | 0.80 | TNK2 (0.54) | IGF1RTNK2 | |
| SCHEMBL3296041 | 0.79 | IGF1R (0.67) | IGF1RROCK2INSRLYNFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781660-A1 | IMIDAZOPYRAZINE AS TYROSINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006012422-A1 | IMIDAZOPYRAZINE AS TYROSINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2006-02-02 | — | — | WO | disclosed |