Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 3/20 | 0.54 |
| ▸ | IGF1R | P08069 | 17/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3296372 | 0.91 | TNK2 (0.67) | TNK2IGF1R | |
| SCHEMBL3299497 | 0.86 | TNK2 (0.73) | TNK2IGF1R | |
| SCHEMBL3297941 | 0.82 | IGF1R (0.70) | TNK2IGF1R | |
| SCHEMBL3296933 | 0.82 | IGF1R (0.68) | TNK2IGF1R | |
| SCHEMBL5200751 | 0.80 | IGF1R (0.59) | TNK2IGF1R | |
| SCHEMBL3295623 | 0.79 | IGF1R (0.76) | TNK2IGF1R | |
| SCHEMBL3296917 | 0.78 | IGF1R (0.75) | TNK2IGF1R | |
| SCHEMBL27704850 | 0.78 | IGF1R (0.65) | TNK2IGF1R | |
| SCHEMBL3299293 | 0.77 | TNK2 (0.65) | TNK2IGF1R | |
| SCHEMBL3303511 | 0.77 | IGF1R (0.75) | TNK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781660-A1 | IMIDAZOPYRAZINE AS TYROSINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006012422-A1 | IMIDAZOPYRAZINE AS TYROSINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2006-02-02 | — | — | WO | disclosed |