Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 17/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4345074 | 0.93 | TGFBR1 (0.71) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL4351447 | 0.85 | TGFBR1 (0.70) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL376161 | 0.83 | TGFBR1 (0.86) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL30194941 | 0.83 | TGFBR1 (0.86) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL18604427 | 0.82 | TGFBR1 (0.62) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL15678349 | 0.82 | TGFBR1 (0.73) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL375627 | 0.82 | TGFBR1 (0.73) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL4347711 | 0.82 | TGFBR1 (0.70) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL19442173 | 0.81 | TGFBR1 (0.64) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL4337372 | 0.81 | TGFBR1 (0.69) | TGFBR1MAPK14RIPK2ACVR1BTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | claimed |