Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14085915 | 0.87 | SIGMAR1 (0.51) | SIGMAR1LTA4HTACR1KDM4EMEN1 | |
| SCHEMBL1189622 | 0.87 | SIGMAR1 (0.51) | SIGMAR1LTA4HTACR1KDM4EMEN1 | |
| SCHEMBL310284 | 0.87 | SIGMAR1 (0.51) | SIGMAR1LTA4HTACR1KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL11446780 | 0.84 | SIGMAR1 (0.49) | SIGMAR1LTA4HTACR1KDM4EMEN1 | |
| SCHEMBL29289212 | 0.84 | SIGMAR1 (0.49) | SIGMAR1LTA4HTACR1KDM4EMEN1 | |
| SCHEMBL10675682 | 0.84 | SIGMAR1 (0.49) | SIGMAR1LTA4HTACR1KDM4EMEN1 | |
| SCHEMBL6335455 | 0.83 | TACR1 (0.55) | SIGMAR1LTA4HTACR1KDM4EACHE | |
| SCHEMBL6335458 | 0.83 | TACR1 (0.55) | SIGMAR1LTA4HTACR1KDM4EACHE | |
| SCHEMBL3494925 | 0.82 | SIGMAR1 (0.46) | SIGMAR1LTA4HTACR1KDM4EMEN1 | |
| SCHEMBL16026440 | 0.82 | SIGMAR1 (0.46) | SIGMAR1LTA4HTACR1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400521-B1 | PIPERAZINE COMPOUNDS | KOWA CO (JP) | 2007-11-07 | — | — | EP | disclosed |
| CN-1309720-C | Piperazine compounds | KOWA CO (JP) | 2007-04-11 | — | — | CN | disclosed |
| CN-1520408-A | Piperazine compounds | ������������ʽ���� | 2004-08-11 | — | — | CN | disclosed |
| EP-1400521-A1 | PIPERAZINE COMPOUNDS | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6432957-B1 | ANTIASTHMA; ANTIALLERGENS; RHEUMATIC DISEASES; ANTIINFLAMMATORY AGENTS | KOWA CO., LTD. (JP) | 2002-08-13 | — | — | US | disclosed |