Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201594 | 0.88 | HTR6 (0.67) | HTR6MEN1KMT2AHTR2ACYP1A2 | |
| SCHEMBL14445203 | 0.86 | HTR6 (0.55) | HTR6HRH4KMT2AHTR2ADRD2 | |
| SCHEMBL5201769 | 0.81 | HTR6 (0.58) | HTR6HTR2ADRD2HTR7HTR2B | |
| SCHEMBL5201209 | 0.81 | HTR6 (0.78) | HTR6HRH4KMT2AHTR2ADRD2 | |
| SCHEMBL5202253 | 0.78 | HTR6 (0.69) | HTR6HSD11B1MEN1KMT2AHTR2A | |
| SCHEMBL5072343 | 0.76 | HTR6 (0.66) | HTR6HSD11B1HTR2ACYP1A2CYP2C19 | |
| SCHEMBL5201506 | 0.75 | HTR6 (0.47) | HTR6HRH4HTR2ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL10776394 | 0.74 | HRH4 (0.58) | HTR6HRH4MEN1KMT2AHTR2A | |
| SCHEMBL5201888 | 0.74 | HTR6 (0.71) | HTR6HRH4HTR2ACYP1A2DRD2 | |
| SCHEMBL4675523 | 0.72 | HTR6 (0.67) | HTR6MEN1KMT2AHTR2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1587788-B9 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2007-10-24 | — | — | EP | claimed |
| EP-1587788-B1 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2007-05-16 | — | — | EP | claimed |
| CN-1314669-C | 2,7-substituted indoles and their use as 5-HT6 modulators | HOFFMANN LA ROCHE (CH) | 2007-05-09 | — | — | CN | claimed |
| EP-1587788-A1 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-26 | — | — | EP | claimed |
| CN-1681782-A | 2, 7-substituted indoles and their use as 5-HT 6 modulators | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | CN | claimed |
| WO-2004026830-A1 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-01 | — | — | WO | claimed |
| EP-1587788-B9 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2007-10-24 | — | — | EP | disclosed |
| US-7247651-B2 | 2,7-substituted indoles | ROCHE PALO ALTO LLC (US) | 2007-07-24 | — | — | US | disclosed |
| US-7247651-B2 | 2,7-substituted indoles | ROCHE PALO ALTO LLC (US) | 2007-07-24 | — | — | US | disclosed |
| EP-1587788-B1 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | HOFFMANN LA ROCHE (CH) | 2007-05-16 | — | — | EP | disclosed |
| CN-1314669-C | 2,7-substituted indoles and their use as 5-HT6 modulators | HOFFMANN LA ROCHE (CH) | 2007-05-09 | — | — | CN | disclosed |
| EP-1587788-A1 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-26 | — | — | EP | disclosed |
| CN-1681782-A | 2, 7-substituted indoles and their use as 5-HT 6 modulators | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | CN | disclosed |
| WO-2004026830-A1 | 2,7-SUBSTITUTED INDOLES AND THEIR USE AS 5-HT6 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-01 | — | — | WO | disclosed |