Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 9/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | MPO | P05164 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38656198 | 1.00 | CYP19A1 (0.56) | CYP19A1MCL1MEN1KMT2AHSD17B10 | |
| SCHEMBL6816523 | 0.87 | CRHBP (0.65) | CYP19A1MEN1KMT2AHSD17B10CYP1A2 | |
| SCHEMBL3237240 | 0.85 | CYP19A1 (0.64) | CYP19A1MEN1KMT2AHSD17B10CYP1A2 | |
| SCHEMBL27183104 | 0.84 | HSD17B10 (0.53) | MCL1MEN1KMT2AHSD17B10SMN1; SMN2 | |
| SCHEMBL8696573 | 0.83 | MCL1 (0.51) | MCL1MEN1KMT2AHSD17B10CYP3A4 | |
| SCHEMBL5201193 | 0.82 | MCL1 (0.59) | CYP19A1MCL1MEN1KMT2AHSD17B10 | |
| SCHEMBL29451324 | 0.82 | MCL1 (0.59) | CYP19A1MCL1MEN1KMT2AHSD17B10 | |
| SCHEMBL17526275 | 0.82 | MCL1 (0.50) | CYP19A1MCL1MEN1KMT2AHSD17B10 | |
| SCHEMBL11932410 | 0.81 | CRHBP (0.61) | CYP19A1MCL1CYP1A2CYP3A4MAPT | |
| SCHEMBL7869881 | 0.81 | CYP19A1 (0.56) | CYP19A1MEN1KMT2AHSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887346-B1 | N-Phenyl-alkylsulfonamide derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | HOFFMANN LA ROCHE (CH) | 2007-12-12 | — | — | EP | disclosed |
| US-6057349-A | ALPHA.SUB.1A/1L AGONISTS USED IN THE TREATMENT OF VARIOUS DISEASE STATES SUCH AS URINARY INCONTINENCE, NASAL CONGESTION, PRIAPISM, DEPRESSION, ANXIETY, DEMENTIA, SENILITY, ALZHEIMER'S, DEFICIENCIES IN ATTENTIVENESS AND COGNITION, AND | F. HOFFMAN LA ROCHE AG (CH) | 2000-05-02 | — | — | US | disclosed |
| US-5952362-A | INHIBITOR OF GLYCOGEN PHOSPHORYLASE ENZYMETIC ACTIVITY AND GLUCOSE ACITIVITY | SYNTEX (U.S.A) INC. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0887346-A2 | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-30 | — | — | EP | disclosed |
| EP-0490936-B1 | PRODUCTION OF TRIAZOLINONES | FMC CORP (US) | 1996-10-23 | — | — | EP | disclosed |
| EP-0490936-A4 | PRODUCTION OF TRIAZOLINONES | — | 1992-10-14 | — | — | EP | disclosed |
| EP-0490936-A1 | PRODUCTION OF TRIAZOLINONES. | FMC CORP (US) | 1992-06-24 | — | — | EP | disclosed |
| WO-1991003470-A1 | PRODUCTION OF TRIAZOLINONES | FMC CORPORATION (US) | 1991-03-21 | — | — | WO | disclosed |
| US-4980480-A | Production of triazolinones | FMC CORPORATION (US) | 1990-12-25 | — | — | US | disclosed |