Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 6/20 | 0.73 |
| ▸ | RET | P07949 | 4/20 | 0.73 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.73 |
| ▸ | FLT3 | P36888 | 3/20 | 0.73 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.73 |
| ▸ | ABL1 | P00519 | 2/20 | 0.73 |
| ▸ | LTK | P29376 | 2/20 | 0.73 |
| ▸ | KDR | P35968 | 2/20 | 0.73 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.73 |
| ▸ | CDK7 | P50613 | 2/20 | 0.73 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.73 |
| ▸ | MST1R | Q04912 | 2/20 | 0.73 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.73 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.73 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.73 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.73 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.73 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.73 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.73 |
| ▸ | LCK | P06239 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7780557 | 0.90 | NTRK1 (0.78) | NTRK1RETPDGFRBFLT3PRKD3 | |
| SCHEMBL14448928 | 0.85 | NTRK1 (0.73) | NTRK1RETPDGFRBFLT3PRKD3 | |
| SCHEMBL5476408 | 0.85 | NTRK1 (0.73) | NTRK1RETPDGFRBFLT3PRKD3 | |
| SCHEMBL5473159 | 0.85 | NTRK1 (0.73) | NTRK1RETPDGFRBFLT3PRKD3 | |
| SCHEMBL5473156 | 0.85 | NTRK1 (0.73) | NTRK1RETPDGFRBFLT3PRKD3 | |
| SCHEMBL14448936 | 0.85 | NTRK1 (0.73) | NTRK1RETPDGFRBFLT3PRKD3 | |
| SCHEMBL5472578 | 0.85 | NTRK1 (0.73) | NTRK1RETPDGFRBFLT3PRKD3 | |
| SCHEMBL5472580 | 0.85 | NTRK1 (0.73) | NTRK1RETPDGFRBFLT3PRKD3 | |
| SCHEMBL5476404 | 0.85 | NTRK1 (0.73) | NTRK1RETPDGFRBFLT3PRKD3 | |
| SCHEMBL7875916 | 0.85 | NTRK1 (0.73) | NTRK1RETPDGFRBFLT3PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0987263-B1 | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors | PFIZER ITALIA SRL (IT) | 2007-04-18 | — | — | EP | claimed |
| EP-0987263-A2 | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-03-22 | — | — | EP | claimed |
| US-5656654-A | TYROSINE KINASE INHIBITORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1997-08-12 | — | — | US | claimed |
| EP-0987263-B1 | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors | PFIZER ITALIA SRL (IT) | 2007-04-18 | — | — | EP | disclosed |
| EP-0987263-A2 | Arylidene and heteroarylidene oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-03-22 | — | — | EP | disclosed |
| US-5656654-A | TYROSINE KINASE INHIBITORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1997-08-12 | — | — | US | disclosed |