Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | PDE4A | P27815 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3163770 | 0.99 | GPR119 (0.49) | GPR119PDE4BPDE4DPDE4APDE4C | |
| Potassium Ion SCHEMBL5201540 | 0.97 | GPR119 (0.48) | GPR119PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3158355 | 0.88 | PDE4B (0.49) | GPR119PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3165435 | 0.85 | PDE4B (0.54) | GPR119PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3164585 | 0.84 | GPR119 (0.51) | GPR119PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL14612780 | 0.84 | GPR119 (0.36) | GPR119PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3165672 | 0.84 | MEN1 (0.53) | GPR119PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3160552 | 0.84 | GPR119 (0.54) | GPR119PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3151575 | 0.84 | PDE4B (0.50) | GPR119PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL4274191 | 0.82 | NPC1 (0.54) | GPR119PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817287-A1 | AROMATIC ETHER DERIVATIVES USEFUL AS THROMBIN INHIBITORS | Eli Lilly and Company (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006057845-A1 | AROMATIC ETHER DERIVATIVES USEFUL AS THROMBIN INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |