Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14185129 | 0.91 | MAPK14 (0.65) | HDAC1HDAC6HTTMAPK14KDM4E | |
| SCHEMBL5202728 | 0.84 | MAPK14 (0.59) | MAPK14 | |
| SCHEMBL6772793 | 0.80 | ACHE (0.54) | HDAC1HDAC6 | |
| SCHEMBL6775597 | 0.78 | MEN1 (0.53) | HTTMAPK14KDM4E | |
| SCHEMBL8445048 | 0.78 | MAPK14 (0.82) | HDAC1HDAC6HTTMAPK14 | |
| Fluorobenzene SCHEMBL27488084 | 0.77 | KDM4E (0.52) | HDAC1HDAC6HTTMAPK14KDM4E | |
| SCHEMBL14357711 | 0.77 | MAPK14 (0.59) | MAPK14 | |
| SCHEMBL14185140 | 0.76 | MAPK14 (0.52) | HDAC1HDAC6MAPK14 | |
| SCHEMBL5203675 | 0.75 | MEN1 (0.63) | HTT | |
| SCHEMBL5203909 | 0.74 | MAPK14 (0.61) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178983-B1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | SCIOS INC (US) | 2007-10-24 | — | — | EP | claimed |