Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 3/20 | 0.42 |
| ▸ | CCNC | P24863 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | SMPD3 | Q9NY59 | 6/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | FPR1 | P21462 | 2/20 | 0.38 |
| ▸ | FPR2 | P25090 | 2/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3561589 | 0.84 | MCHR1 (0.47) | EEDCCNCCDK8SMPD3FPR1 | |
| Bicarbonate SCHEMBL3556227 | 0.81 | CCNC (0.43) | EEDCCNCCDK8SMPD3USP30 | |
| SCHEMBL5201848 | 0.78 | CCNC (0.42) | EEDCCNCCDK8SMPD3USP30 | |
| SCHEMBL3931285 | 0.72 | USP30 (0.49) | EEDUSP30 | |
| SCHEMBL3931291 | 0.72 | USP30 (0.49) | EEDUSP30 | |
| SCHEMBL3555997 | 0.71 | EED (0.39) | EEDCCNCCDK8SMPD3USP30 | |
| SCHEMBL3555998 | 0.71 | CCNC (0.37) | EEDCCNCCDK8SMPD3USP30 | |
| SCHEMBL4579609 | 0.69 | MCHR1 (0.50) | SMPD3FPR1FPR2KCNH2 | |
| SCHEMBL27258755 | 0.69 | DRD2 (0.59) | SMPD3USP30ACACB | |
| SCHEMBL19711007 | 0.68 | NOTUM (0.61) | EEDSMPD3ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |