Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | SELE | P16581 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11787237 | 0.78 | GAA (0.41) | ICAM1SELESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4354057 | 0.72 | AOC3 (0.47) | L3MBTL1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL24711387 | 0.72 | SLC6A4 (0.55) | PTGS1PTGS2 | |
| SCHEMBL9102850 | 0.70 | NPSR1 (0.49) | L3MBTL1TDP1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL475215 | 0.69 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1LMNAMAPTNPC1 | |
| SCHEMBL8925998 | 0.69 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1LMNAMAPTNPC1 | |
| SCHEMBL11419701 | 0.68 | LPAR1 (0.52) | L3MBTL1TDP1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3081479 | 0.68 | — | — | |
| SCHEMBL2056280 | 0.68 | MAOB (0.52) | L3MBTL1TDP1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL31579782 | 0.68 | SMN1; SMN2 (0.54) | L3MBTL1TDP1SMN1; SMN2ALDH1A1NPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | disclosed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |
| US-6583148-B1 | Neurodegenerative or other neurological disorders; enhancing the effect of nerve growth factor; 2-Amino-5-(4-chlorophenoxy)-4-trans-4-hydroxycyclohexylamino) pyrimidine | KRENITSKY PHARMACEUTICALS, INC. | 2003-06-24 | — | — | US | disclosed |
| EP-1165523-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000061562-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-19 | — | — | WO | disclosed |