Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 8/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 7/20 | 0.34 |
| ▸ | FLT3 | P36888 | 4/20 | 0.34 |
| ▸ | GAS6 | Q14393 | 4/20 | 0.34 |
| ▸ | BTK | Q06187 | 3/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 3/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CCNH | P51946 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202101 | 1.00 | MERTK (0.34) | MERTKTYRO3FLT3GAS6BTK | |
| SCHEMBL5202107 | 1.00 | MERTK (0.34) | MERTKTYRO3FLT3GAS6BTK | |
| SCHEMBL3254181 | 0.81 | MERTK (0.34) | MERTKTYRO3FLT3GAS6AXL | |
| SCHEMBL3254176 | 0.81 | MERTK (0.34) | MERTKTYRO3FLT3GAS6AXL | |
| SCHEMBL3254180 | 0.81 | MERTK (0.34) | MERTKTYRO3FLT3GAS6AXL | |
| SCHEMBL5202927 | 0.78 | L3MBTL1 (0.35) | CCNCCDK8 | |
| SCHEMBL5202933 | 0.78 | L3MBTL1 (0.35) | CCNCCDK8 | |
| SCHEMBL1376243 | 0.76 | BTK (0.40) | MERTKTYRO3FLT3GAS6BTK | |
| SCHEMBL5203150 | 0.76 | BTK (0.40) | MERTKTYRO3FLT3GAS6BTK | |
| SCHEMBL1376242 | 0.76 | BTK (0.40) | MERTKTYRO3FLT3GAS6BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | disclosed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |
| US-6583148-B1 | Neurodegenerative or other neurological disorders; enhancing the effect of nerve growth factor; 2-Amino-5-(4-chlorophenoxy)-4-trans-4-hydroxycyclohexylamino) pyrimidine | KRENITSKY PHARMACEUTICALS, INC. | 2003-06-24 | — | — | US | disclosed |