Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 14/20 | 0.55 |
| ▸ | DPP8 | Q6V1X1 | 8/20 | 0.53 |
| ▸ | DPP9 | Q86TI2 | 6/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
| ▸ | MARS1 | P56192 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4912438 | 0.99 | DPP4 (0.54) | DPP4DPP8DPP9CYP3A4CNR1 | |
| SCHEMBL5189117 | 0.91 | DPP4 (0.57) | DPP4DPP8DPP9CYP3A4CNR1 | |
| SCHEMBL4934709 | 0.90 | DPP4 (0.48) | DPP4DPP8DPP9CYP3A4 | |
| Hydrochloric Acid SCHEMBL4918479 | 0.89 | DPP4 (0.47) | DPP4DPP8DPP9CYP3A4 | |
| SCHEMBL4906797 | 0.86 | DPP4 (0.53) | DPP4DPP8DPP9CYP3A4CNR1 | |
| SCHEMBL5187409 | 0.86 | DPP4 (0.44) | DPP4DPP8DPP9CRHR1 | |
| Hydrochloric Acid SCHEMBL4913608 | 0.85 | DPP4 (0.43) | DPP4DPP8DPP9CRHR1 | |
| SCHEMBL4912767 | 0.83 | DPP4 (0.52) | DPP4DPP8DPP9CYP3A4CNR1 | |
| SCHEMBL3106224 | 0.82 | DPP4 (0.47) | DPP4CNR1CNR2CRHR1 | |
| SCHEMBL4911607 | 0.79 | HSD11B1 (0.43) | DPP4DPP8DPP9CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805143-A1 | PYRIDINE DERIVATIVES AND THE PREPARATION AND THE THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006042955-A1 | PYRIDINE DERIVATIVES AND THE PREPARATION AND THE THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2006-04-27 | — | — | WO | disclosed |