Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.49 |
| ▸ | CDK4 | P11802 | 5/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL409778 | 0.84 | CDK2 (0.57) | CDK2CDK4CCNE1HDAC1IGF1R | |
| SCHEMBL410999 | 0.74 | CDK2 (0.47) | CDK2CDK4KDM4EALDH1A1CCNE1 | |
| SCHEMBL412361 | 0.73 | CDK2 (0.71) | CDK2CDK4KDM4EALDH1A1CCNE1 | |
| SCHEMBL415435 | 0.73 | CDK2 (0.51) | CDK2CDK4TGFBR1CCNE1IGF1R | |
| SCHEMBL3360699 | 0.71 | HDAC1 (0.54) | CDK2CDK4CCNE1HDAC1CDK19 | |
| SCHEMBL409738 | 0.70 | HDAC1 (0.56) | CDK2CDK4CCNE1HDAC1 | |
| SCHEMBL413663 | 0.70 | ALDH1A1 (0.52) | CDK2CDK4KDM4EALDH1A1CCNE1 | |
| SCHEMBL413077 | 0.70 | DYRK1A (0.53) | CDK2CDK4KDM4EALDH1A1CCNE1 | |
| SCHEMBL408673 | 0.70 | HDAC1 (0.53) | CDK2CDK4CCNE1HDAC1CDK19 | |
| SCHEMBL411464 | 0.69 | CDK2 (0.75) | CDK2CDK4TGFBR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | claimed |