Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 3/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CCND1 | P24385 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5319326 | 0.87 | TGFBR1 (0.42) | TGFBR1CDK1CCNB1CCNB2CCNB3 | |
| SCHEMBL5139923 | 0.85 | TGFBR1 (0.47) | TGFBR1CDK1CCNB1CCNB2CCNB3 | |
| SCHEMBL5138148 | 0.84 | TGFBR1 (0.56) | TGFBR1CDK1CCNB1CCNB2CCNB3 | |
| SCHEMBL5148794 | 0.84 | MAPK14 (0.40) | BRAFTGFBR1CDK1CCNB1CCNB2 | |
| SCHEMBL5137968 | 0.83 | TGFBR1 (0.46) | TGFBR1CDK1CCNB1CCNB2CCNB3 | |
| SCHEMBL5138562 | 0.83 | TGFBR1 (0.46) | BRAFTGFBR1CDK1CCNB1CCNB2 | |
| SCHEMBL5138494 | 0.81 | TGFBR1 (0.46) | BRAFTGFBR1CDK1CCNB1CCNB2 | |
| SCHEMBL5199691 | 0.80 | MAPK14 (0.40) | BRAFTGFBR1MAPK8MAPK9MAPK10 | |
| SCHEMBL4335540 | 0.77 | TGFBR1 (0.54) | TGFBR1MAPK14 | |
| SCHEMBL4351447 | 0.73 | TGFBR1 (0.70) | TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | claimed |
| EP-1786802-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | Biogen Idec MA, Inc. (US) | 2007-05-23 | — | — | EP | claimed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | claimed |
| WO-2006026306-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | BIOGEN IDEC MA INC. (US) | 2006-03-09 | — | — | WO | claimed |
| EP-1786802-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | Biogen Idec MA, Inc. (US) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006026306-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | BIOGEN IDEC MA INC. (US) | 2006-03-09 | — | — | WO | disclosed |