Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 14/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ARAF | P10398 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL412692 | 0.84 | AKT1 (0.38) | AKT1AKT2HTR6TGFBR1MAPK14 | |
| SCHEMBL5792276 | 0.84 | MAP3K14 (0.46) | AKT1AKT2HTR6TGFBR1MAPK14 | |
| SCHEMBL5794919 | 0.81 | HTR6 (0.39) | AKT1AKT2HTR6TGFBR1MAPK14 | |
| SCHEMBL414173 | 0.74 | CDK2 (0.46) | TGFBR1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL412821 | 0.71 | MAPK14 (0.68) | TGFBR1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5793074 | 0.70 | MAPK13 (0.40) | TGFBR1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL415422 | 0.67 | GSK3B (0.41) | TGFBR1KDR | |
| SCHEMBL415270 | 0.67 | GSK3B (0.41) | — | |
| SCHEMBL411283 | 0.66 | MAP3K14 (0.41) | TGFBR1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL414090 | 0.63 | MAP3K14 (0.70) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | claimed |
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | disclosed |