Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13685456 | 0.92 | GPR119 (0.51) | GPR119CYP2C9KCNH2ALDH1A1LMNA | |
| SCHEMBL390438 | 0.90 | GPR119 (0.62) | GPR119CYP2C9KCNH2ALDH1A1LMNA | |
| SCHEMBL391174 | 0.82 | GPR119 (0.64) | GPR119CYP2C9KCNH2ALDH1A1LMNA | |
| SCHEMBL386631 | 0.81 | GPR119 (0.62) | GPR119CYP2C9KCNH2ALDH1A1LMNA | |
| SCHEMBL5665757 | 0.79 | GPR119 (0.65) | GPR119CYP2C9KCNH2ALDH1A1LMNA | |
| SCHEMBL27747902 | 0.78 | GPR119 (0.62) | GPR119CYP2C9KCNH2ALDH1A1LMNA | |
| SCHEMBL390792 | 0.78 | GPR119 (0.69) | GPR119CYP2C9KCNH2HIF1AKDM4E | |
| SCHEMBL1071139 | 0.77 | GPR119 (0.62) | GPR119CYP2C9KCNH2ALDH1A1LMNA | |
| SCHEMBL389560 | 0.77 | GPR119 (0.65) | GPR119CYP2C9KCNH2ALDH1A1LMNA | |
| SCHEMBL389426 | 0.77 | GPR119 (0.58) | GPR119CYP2C9KCNH2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758565-A2 | COMBINATION THERAPY FOR THE TREATMENT OF DIABETES AND CONDITIONS RELATED THERETO AND FOR THE TREATMENT OF CONDITIONS AMELIORATED BY INCREASING A BLOOD GLP-1 LEVEL | Arena Pharmaceuticals, Inc. (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006076231-A2 | COMBINATION THERAPY FOR THE TREATMENT OF DIABETES AND CONDITIONS RELATED THERETO AND FOR THE TREATMENT OF CONDITIONS AMELIORATED BY INCREASING A BLOOD GLP-1 LEVEL | ARENA PHARMACEUTICALS, INC. (US) | 2006-07-20 | — | — | WO | disclosed |