Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 4/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 3/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.37 |
| ▸ | CBR1 | P16152 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203216 | 1.00 | MERTK (0.39) | MERTKAXLFLT3TYRO3GAS6 | |
| Hydrochloric Acid SCHEMBL5207002 | 0.99 | MERTK (0.38) | MERTKAXLFLT3TYRO3GAS6 | |
| Hydrochloric Acid SCHEMBL5206994 | 0.99 | MERTK (0.38) | MERTKAXLFLT3TYRO3GAS6 | |
| SCHEMBL5203513 | 0.89 | MAPK14 (0.43) | MERTKAXLFLT3TYRO3GAS6 | |
| SCHEMBL1376409 | 0.89 | MERTK (0.39) | MERTKAXLFLT3TYRO3GAS6 | |
| SCHEMBL1376410 | 0.89 | MERTK (0.39) | MERTKAXLFLT3TYRO3GAS6 | |
| SCHEMBL7161091 | 0.89 | MAPK14 (0.43) | MERTKAXLFLT3TYRO3GAS6 | |
| SCHEMBL5203505 | 0.89 | MAPK14 (0.43) | MERTKAXLFLT3TYRO3GAS6 | |
| SCHEMBL7161086 | 0.89 | MAPK14 (0.43) | MERTKAXLFLT3TYRO3GAS6 | |
| SCHEMBL5205128 | 0.87 | PDE5A (0.42) | MERTKAXLFLT3TYRO3GAS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | claimed |
| US-6583148-B1 | Neurodegenerative or other neurological disorders; enhancing the effect of nerve growth factor; 2-Amino-5-(4-chlorophenoxy)-4-trans-4-hydroxycyclohexylamino) pyrimidine | KRENITSKY PHARMACEUTICALS, INC. | 2003-06-24 | — | — | US | claimed |
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | disclosed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |
| US-6583148-B1 | Neurodegenerative or other neurological disorders; enhancing the effect of nerve growth factor; 2-Amino-5-(4-chlorophenoxy)-4-trans-4-hydroxycyclohexylamino) pyrimidine | KRENITSKY PHARMACEUTICALS, INC. | 2003-06-24 | — | — | US | disclosed |
| EP-1165523-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000061562-A1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-19 | — | — | WO | disclosed |