Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 10/20 | 0.42 |
| ▸ | MERTK | Q12866 | 6/20 | 0.39 |
| ▸ | FLT3 | P36888 | 5/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.39 |
| ▸ | GAS6 | Q14393 | 5/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205130 | 1.00 | PDE5A (0.42) | PDE5AMERTKFLT3TYRO3GAS6 | |
| SCHEMBL1377648 | 0.92 | MAPK14 (0.39) | PDE5AMERTKFLT3TYRO3GAS6 | |
| SCHEMBL1377646 | 0.92 | MAPK14 (0.39) | PDE5AMERTKFLT3TYRO3GAS6 | |
| SCHEMBL5203220 | 0.87 | MERTK (0.39) | MERTKFLT3TYRO3GAS6AXL | |
| SCHEMBL5203216 | 0.87 | MERTK (0.39) | MERTKFLT3TYRO3GAS6AXL | |
| Hydrochloric Acid SCHEMBL5207002 | 0.86 | MERTK (0.38) | PDE5AMERTKFLT3TYRO3GAS6 | |
| Hydrochloric Acid SCHEMBL5206994 | 0.86 | MERTK (0.38) | PDE5AMERTKFLT3TYRO3GAS6 | |
| SCHEMBL7161091 | 0.85 | MAPK14 (0.43) | MERTKFLT3TYRO3GAS6AXL | |
| SCHEMBL7161086 | 0.85 | MAPK14 (0.43) | MERTKFLT3TYRO3GAS6AXL | |
| SCHEMBL7157258 | 0.85 | MERTK (0.42) | MERTKFLT3TYRO3GAS6AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | claimed |
| US-6583148-B1 | Neurodegenerative or other neurological disorders; enhancing the effect of nerve growth factor; 2-Amino-5-(4-chlorophenoxy)-4-trans-4-hydroxycyclohexylamino) pyrimidine | KRENITSKY PHARMACEUTICALS, INC. | 2003-06-24 | — | — | US | claimed |
| EP-1165523-B1 | NEUROTROPHIC SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC (US) | 2007-11-07 | — | — | EP | disclosed |
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |
| US-6583148-B1 | Neurodegenerative or other neurological disorders; enhancing the effect of nerve growth factor; 2-Amino-5-(4-chlorophenoxy)-4-trans-4-hydroxycyclohexylamino) pyrimidine | KRENITSKY PHARMACEUTICALS, INC. | 2003-06-24 | — | — | US | disclosed |