Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205720 | 0.88 | PIK3CD (0.55) | PIK3CDHSD11B1IKBKETBK1CETP | |
| SCHEMBL5205939 | 0.85 | PIK3CD (0.74) | PIK3CDHSD11B1IKBKETBK1CETP | |
| SCHEMBL5200658 | 0.84 | PIK3CD (0.75) | PIK3CDHSD11B1IKBKETBK1CETP | |
| SCHEMBL5203780 | 0.84 | PIK3CD (0.75) | PIK3CDHSD11B1IKBKETBK1CETP | |
| SCHEMBL5202288 | 0.84 | PIK3CD (0.75) | PIK3CDHSD11B1IKBKETBK1CETP | |
| SCHEMBL5201356 | 0.83 | PIK3CD (0.59) | PIK3CDHSD11B1IKBKETBK1CETP | |
| SCHEMBL5203988 | 0.80 | PIK3CD (0.61) | PIK3CDIKBKETBK1CETP | |
| SCHEMBL5203254 | 0.79 | PIK3CD (0.60) | PIK3CDHSD11B1IKBKETBK1CETP | |
| SCHEMBL5206510 | 0.78 | PIK3CD (0.59) | PIK3CDHSD11B1IKBKETBK1CETP | |
| SCHEMBL5206517 | 0.77 | PIK3CD (0.57) | PIK3CDHSD11B1IKBKETBK1CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682532-B1 | PYRIMIDINES AS INHIBITORS OF PHOSPHOINOSITIDE-3-KINASES (PI3K) | WARNER LAMBERT CO (US) | 2007-06-27 | — | — | EP | claimed |