Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.55 |
| ▸ | PDE4A | P27815 | 9/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202917 | 0.91 | MAOB (0.56) | PDE4BALDH1A1LMNAPKMNPSR1 | |
| SCHEMBL6602629 | 0.90 | PDE4B (0.55) | PDE4BPDE4DPDE4APDE4CALDH1A1 | |
| SCHEMBL6584543 | 0.87 | PDE5A (0.52) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7646579 | 0.86 | ALDH1A1 (0.48) | ALDH1A1LMNAPKMNPSR1MAOB | |
| SCHEMBL6607012 | 0.86 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CALDH1A1 | |
| SCHEMBL6602063 | 0.86 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CALDH1A1 | |
| SCHEMBL5202716 | 0.85 | ALDH1A1 (0.49) | PDE4BALDH1A1LMNAPKMNPSR1 | |
| SCHEMBL5206295 | 0.85 | ALDH1A1 (0.49) | PDE4BALDH1A1LMNAPKMNPSR1 | |
| SCHEMBL6601661 | 0.85 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4CMAOB | |
| SCHEMBL14553640 | 0.85 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4CMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087946-B1 | ARYL ALKANOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2007-01-10 | — | — | EP | disclosed |
| EP-0922036-B1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| US-6479494-B1 | THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-12 | — | — | US | disclosed |
| EP-1143944-A3 | USE OF ARYLALKANOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2002-09-11 | — | — | EP | disclosed |
| US-6417188-B1 | ENZYME INHIBITORS OF PHOSPHODIESTERASE | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-07-09 | — | — | US | disclosed |
| EP-1143944-A2 | USE OF ARYLALKANOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2001-10-17 | — | — | EP | disclosed |
| EP-1087946-A1 | ARYL ALKANOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2001-04-04 | — | — | EP | disclosed |
| WO-2000059484-A2 | USE OF ARYLALKANOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2000-10-12 | — | — | WO | disclosed |
| US-6107295-A | Arylalkanoyl pyridazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-22 | — | — | US | disclosed |
| WO-1999065880-A1 | ARYL ALKANOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 1999-12-23 | — | — | WO | disclosed |
| EP-0922036-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GmbH (DE) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998006704-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |