Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14924423 | 0.80 | LRRK2 (0.41) | MAPTHRH3ADRB1CYP19A1 | |
| SCHEMBL5200511 | 0.80 | MAPT (0.45) | MAPTKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL14924422 | 0.80 | LRRK2 (0.41) | MAPTHRH3ADRB1CYP19A1 | |
| Hydrochloric Acid SCHEMBL6323525 | 0.77 | MEN1 (0.44) | MAPTKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL14923976 | 0.77 | HRH3 (0.42) | MAPTKMT2AHRH3ALDH1A1MAPK1 | |
| SCHEMBL14923987 | 0.77 | HRH3 (0.42) | MAPTKMT2AHRH3ALDH1A1MAPK1 | |
| SCHEMBL2127519 | 0.76 | MAPT (0.59) | MAPTKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL5832442 | 0.76 | MEN1 (0.57) | MAPTKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL2128163 | 0.76 | MEN1 (0.45) | MAPTKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL5200445 | 0.74 | RAD52 (0.42) | MAPTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1378230-B1 | Para-phenylenediamine derivatives comprising a pyrrolidinyl group substituted by a cyclic radical and their use in colouring keratinic fibres | OREAL (FR) | 2007-11-14 | — | — | EP | disclosed |
| US-7132534-B2 | Para-phenylenediamine derivatives containing a pyrrolidyl group, and use of these derivatives for coloring keratin fibers | L'OREAL (FR) | 2006-11-07 | — | — | US | disclosed |
| US-6923835-B2 | Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres | L'OREAL S.A. (FR) | 2005-08-02 | — | — | US | disclosed |
| US-20040123401-A1 | Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres | L'OREAL S.A. (FR) | 2004-07-01 | — | — | US | disclosed |
| US-20040077852-A1 | Para-phenylenediamine derivatives containing a pyrrolidyl group, and use of these derivatives for coloring keratin fibers | L'OREAL S.A. (FR) | 2004-04-22 | — | — | US | disclosed |
| EP-1396486-A1 | Bis-paraphenylendiamine derivatives comprising pyrrolidine groups and their use for the colouration of keratinic fibres | L'OREAL (FR) | 2004-03-10 | — | — | EP | disclosed |
| EP-1378230-A1 | Para-phenylenediamine derivatives comprising a pyrrolidinyl group substituted by a cyclic radical and their use in colouring keratinic fibres | L'OREAL (FR) | 2004-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077852-A1 | Para-phenylenediamine derivatives containing a pyrrolidyl group, and use of these derivatives for coloring keratin fibers | KRT18, CDC73, VIM | MAPT 1211/4885KMT2A 1469/4885MEN1 4520/4885 |
| US-20040123401-A1 | Bis-para-phenylenediamine derivatives comprising a pyrrolidyl group and use of these derivatives for dyeing keratin fibres | KRT18, VIM, CDC73 | MAPT 808/4885KMT2A 1629/4885MEN1 4459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.