Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.50 |
| ▸ | CKS1B | P61024 | 1/20 | 0.49 |
| ▸ | SKP1 | P63208 | 1/20 | 0.49 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8603748 | 0.93 | KDM4D (0.53) | ALDH1A1KDM4DCKS1BSKP1SKP2 | |
| SCHEMBL14155926 | 0.93 | KDM4D (0.53) | ALDH1A1KDM4DCKS1BSKP1SKP2 | |
| SCHEMBL383106 | 0.89 | USP2 (0.56) | CKS1BSKP1SKP2GPR119NAMPT | |
| SCHEMBL3769327 | 0.89 | GPR119 (0.62) | ALDH1A1CKS1BSKP1SKP2GPR119 | |
| SCHEMBL381643 | 0.88 | CKS1B (0.48) | ALDH1A1CKS1BSKP1SKP2GPR119 | |
| SCHEMBL5204853 | 0.88 | GPR119 (0.63) | CKS1BSKP1SKP2GPR119BTK | |
| SCHEMBL17557723 | 0.86 | MAPT (0.56) | ALDH1A1CKS1BSKP1SKP2GPR119 | |
| SCHEMBL15631969 | 0.86 | BTK (0.61) | ALDH1A1KDM4DBTKCTSK | |
| SCHEMBL3282162 | 0.86 | KDM4D (0.51) | KDM4DCKS1BSKP1SKP2GPR119 | |
| SCHEMBL3130708 | 0.86 | CKS1B (0.52) | CKS1BSKP1SKP2GPR119NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682955-B2 | Quinazoline derivatives useful as CB-1 inverse agonists | JANSSEN PHARMACEUTICA NV (BE) | 2017-06-20 | — | — | US | disclosed |
| WO-2016040081-A1 | QUINAZOLINE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-17 | — | — | WO | disclosed |
| US-20160068512-A1 | Quinazoline Derivatives Useful as CB-1 Inverse Agonists | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-10 | — | — | US | disclosed |
| EP-1242083-B1 | PHENOXYPROPANOLAMINES, METHOD FOR PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI AVENTIS (FR) | 2007-03-14 | — | — | EP | disclosed |
| US-6867220-B2 | Phenoxypropanolamines, method for producing them and pharmaceutical compositions containing them | SANOFI-SYNTHELABO (FR) | 2005-03-15 | — | — | US | disclosed |
| US-20030040530-A1 | Phenoxypropanolamines, method for producing them and pharmaceutical compositions containning them | SANOFI-AVENTIS (FR) | 2003-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030040530-A1 | Phenoxypropanolamines, method for producing them and pharmaceutical compositions containning them | CNR1, CORO1C, CBR1 | ALDH1A1 1619/4885KDM4D 1065/4885CKS1B 1466/4885 |
| US-20160068512-A1 | Quinazoline Derivatives Useful as CB-1 Inverse Agonists | CNR1, CNR2, GPR119 | ALDH1A1 1414/4885KDM4D 3741/4885CKS1B 1356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.