Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932594 | 0.85 | GAA (0.70) | GAASMN1; SMN2MEN1KMT2ACHRNA7 | |
| SCHEMBL4962589 | 0.80 | GAA (0.68) | GAASMN1; SMN2MEN1KMT2ACHRNA7 | |
| SCHEMBL5802421 | 0.77 | GAA (0.61) | GAASMN1; SMN2MEN1KMT2ACHRNA7 | |
| SCHEMBL6135838 | 0.77 | GAA (0.61) | GAASMN1; SMN2MEN1KMT2ACHRNA7 | |
| SCHEMBL8252682 | 0.77 | GAA (0.68) | GAASMN1; SMN2MEN1KMT2ACHRNA7 | |
| SCHEMBL5127058 | 0.77 | GAA (0.64) | GAASMN1; SMN2MEN1KMT2ACHRNA7 | |
| SCHEMBL7955416 | 0.77 | GAA (0.64) | GAAMEN1KMT2A | |
| SCHEMBL7441926 | 0.76 | CHRNA7 (0.54) | CHRNA7 | |
| SCHEMBL7448345 | 0.76 | CHRNA7 (0.54) | CHRNA7 | |
| SCHEMBL4958840 | 0.72 | MEN1 (0.68) | GAASMN1; SMN2MEN1KMT2ACHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299100-B1 | METHOD OF TREATING HOT FLASHES, USING TACHYKININ RECEPTOR ANTAGONIST | UNIV ROCHESTER (US) | 2007-07-25 | — | — | EP | disclosed |
| EP-1299100-A4 | METHOD OF TREATING SYMPTOMS OF HORMONAL VARIATION, INCLUDING HOT FLASHES, USING TACHYKININ RECEPTOR ANTAGONIST | UNIV ROCHESTER (US) | 2005-01-12 | — | — | EP | disclosed |
| US-20030236237-A1 | Method of treating symptoms of hormonal variation, including hot flashes, using tachykinin receptor antagonist | GUTTUSO THOMAS J (US) | 2003-12-25 | — | — | US | disclosed |
| EP-1299100-A1 | METHOD OF TREATING SYMPTOMS OF HORMONAL VARIATION, INCLUDING HOT FLASHES, USING TACHYKININ RECEPTOR ANTAGONIST | THE UNIVERSITY OF ROCHESTER (US) | 2003-04-09 | — | — | EP | disclosed |
| US-20020016283-A1 | Method of treating symptoms of hormonal variation, including hot flashes, using tachykinin receptor antagonist | UNIVERSITY OF ROCHESTER | 2002-02-07 | — | — | US | disclosed |
| WO-2001095904-A1 | METHOD OF TREATING SYMPTOMS OF HORMONAL VARIATION, INCLUDING HOT FLASHES, USING TACHYKININ RECEPTOR ANTAGONIST | UNIVERSITY OF ROCHESTER (US) | 2001-12-20 | — | — | WO | disclosed |