Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201330 | 0.92 | MAPK14 (0.53) | MAPK14CYP2C9CYP2C19KDM4EALDH1A1 | |
| SCHEMBL5202149 | 0.91 | MAPK14 (0.51) | MAPK14CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL5201020 | 0.89 | MAPK14 (0.56) | MAPK14CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL5205465 | 0.89 | MAPK14 (0.50) | MAPK14CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL5203602 | 0.88 | MAPK14 (0.51) | MAPK14CYP2C9CYP2C19KDM4EALDH1A1 | |
| SCHEMBL5202617 | 0.87 | MAPK14 (0.56) | MAPK14CYP2C9CYP2C19KDM4EALDH1A1 | |
| SCHEMBL5204726 | 0.86 | MAPK14 (0.56) | MAPK14CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL5203992 | 0.86 | MAPK14 (0.56) | MAPK14CYP2C9CYP2C19KDM4EALDH1A1 | |
| SCHEMBL5202103 | 0.85 | MAPK14 (0.51) | MAPK14CYP2C9CYP2C19KMT2AL3MBTL1 | |
| SCHEMBL5201216 | 0.85 | MAPK14 (0.51) | MAPK14CYP2C9CYP2C19ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178983-B1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | SCIOS INC (US) | 2007-10-24 | — | — | EP | claimed |