Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203602 | 0.93 | MAPK14 (0.51) | MAPK14CYP2C9CYP2C19L3MBTL1ALDH1A1 | |
| SCHEMBL5205465 | 0.92 | MAPK14 (0.50) | MAPK14CYP2C9CYP2C19L3MBTL1CHRM2 | |
| SCHEMBL5202103 | 0.92 | MAPK14 (0.51) | MAPK14CYP2C9CYP2C19L3MBTL1CHRM2 | |
| SCHEMBL5205621 | 0.89 | MAPK14 (0.53) | MAPK14CYP2C9CYP2C19ALOX5L3MBTL1 | |
| SCHEMBL5205422 | 0.89 | MAPK14 (0.47) | MAPK14CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL5203992 | 0.87 | MAPK14 (0.56) | MAPK14CYP2C9CYP2C19ALOX5ALDH1A1 | |
| SCHEMBL5204360 | 0.85 | MAPK14 (0.50) | MAPK14CYP2C9CYP2C19L3MBTL1ALDH1A1 | |
| SCHEMBL5205103 | 0.84 | MAPK14 (0.46) | MAPK14ALOX5ALDH1A1MAPT | |
| SCHEMBL5204693 | 0.83 | MAPK14 (0.52) | MAPK14CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL5205224 | 0.82 | MAPK14 (0.53) | MAPK14CYP2C9CYP2C19L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178983-B1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | SCIOS INC (US) | 2007-10-24 | — | — | EP | claimed |