Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 0.51 |
| ▸ | TOP2A | P11388 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3553245 | 1.00 | TOP1 (0.51) | TOP1TOP2AALDH1A1MAPTLMNA | |
| SCHEMBL4297531 | 0.91 | ALDH1A1 (0.59) | TOP1TOP2AALDH1A1MAPTLMNA | |
| SCHEMBL4297536 | 0.91 | ALDH1A1 (0.59) | TOP1TOP2AALDH1A1MAPTLMNA | |
| SCHEMBL9984672 | 0.83 | ALDH1A1 (0.66) | ALDH1A1MAPTLMNAKMT2APOLB | |
| Trifluoroacetic Acid SCHEMBL3555102 | 0.82 | MAPT (0.49) | ALDH1A1MAPTLMNAKMT2APOLB | |
| Trifluoroacetic Acid SCHEMBL3552142 | 0.82 | MAPT (0.49) | ALDH1A1MAPTLMNAKMT2APOLB | |
| SCHEMBL7815260 | 0.79 | ALDH1A1 (0.49) | ALDH1A1MAPTLMNAKMT2APOLB | |
| SCHEMBL854197 | 0.78 | ALDH1A1 (0.59) | ALDH1A1MAPTLMNAKMT2APOLB | |
| SCHEMBL7805532 | 0.78 | ALDH1A1 (0.59) | ALDH1A1MAPTLMNAKMT2APOLB | |
| SCHEMBL9987106 | 0.77 | TDP1 (0.74) | ALDH1A1MAPTLMNAKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |