Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14038733 | 0.90 | BRAF (0.65) | BRAFHRH3MAPK3MAPK1MAPK11 | |
| SCHEMBL6596438 | 0.88 | BRAF (0.61) | BRAFHRH3MAPK3MAPK1MAPK11 | |
| SCHEMBL5203996 | 0.88 | BRAF (0.71) | BRAFHRH3MAPK3MAPK1PDE4D | |
| SCHEMBL5204126 | 0.88 | BRAF (0.85) | BRAFMAPK3MAPK1 | |
| SCHEMBL5108371 | 0.88 | BRAF (0.85) | BRAFMAPK3MAPK1 | |
| SCHEMBL5108377 | 0.88 | BRAF (0.85) | BRAFMAPK3MAPK1 | |
| SCHEMBL5106246 | 0.87 | BRAF (0.51) | BRAFHRH3MAPK3MAPK1PDE4D | |
| SCHEMBL5114990 | 0.86 | BRAF (0.49) | BRAFHRH3MAPK3MAPK1MAPK14 | |
| SCHEMBL5202346 | 0.85 | BRAF (0.68) | BRAFHRH3MAPK3MAPK1 | |
| SCHEMBL5103604 | 0.84 | BRAF (0.47) | BRAFHRH3CYP1A2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423384-B1 | PYRIDINE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2007-05-23 | — | — | EP | disclosed |
| EP-1423384-A1 | PYRIDINE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003022840-A1 | PYRIDINE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2003-03-20 | — | — | WO | disclosed |