Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.68 |
| ▸ | MAPK3 | P27361 | 8/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204126 | 0.89 | BRAF (0.85) | BRAFMAPK3MAPK1 | |
| SCHEMBL5241458 | 0.89 | BRAF (0.74) | BRAFMAPK3MAPK1 | |
| SCHEMBL5108377 | 0.89 | BRAF (0.85) | BRAFMAPK3MAPK1 | |
| SCHEMBL5108371 | 0.89 | BRAF (0.85) | BRAFMAPK3MAPK1 | |
| SCHEMBL5204518 | 0.85 | BRAF (0.65) | BRAFMAPK3MAPK1HRH3 | |
| SCHEMBL6596438 | 0.85 | BRAF (0.61) | BRAFMAPK3MAPK1HRH3 | |
| SCHEMBL14038733 | 0.82 | BRAF (0.65) | BRAFMAPK3MAPK1HRH3 | |
| SCHEMBL5106641 | 0.81 | BRAF (0.76) | BRAFMAPK3MAPK1 | |
| SCHEMBL5202352 | 0.81 | BRAF (0.76) | BRAFMAPK3MAPK1 | |
| SCHEMBL5106650 | 0.81 | BRAF (0.76) | BRAFMAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423384-B1 | PYRIDINE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2007-05-23 | — | — | EP | disclosed |
| US-20040235843-A1 | Pyridine derivatives as raf kinase inhibitors | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235843-A1 | Pyridine derivatives as raf kinase inhibitors | BRAF, RAF1, ARAF | BRAF 1/4885MAPK3 57/4885MAPK1 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.