Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204522 | 1.00 | MAPT (0.50) | MAPTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL5202437 | 0.89 | MEN1 (0.51) | MAPTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL5202444 | 0.89 | MEN1 (0.51) | MAPTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL5202448 | 0.89 | MEN1 (0.51) | MAPTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL7166364 | 0.89 | MAPT (0.41) | MAPTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL7166367 | 0.89 | MAPT (0.41) | MAPTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL5204078 | 0.85 | MAPT (0.52) | MAPTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL5204074 | 0.85 | MAPT (0.52) | MAPTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL7159472 | 0.85 | KMT2A (0.50) | MAPTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL5202109 | 0.84 | MAPT (0.46) | MAPTSMN1; SMN2LMNAALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1223944-B1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2007-01-03 | — | — | EP | claimed |
| US-6552008-B1 | Administering effective amount of a selected azo-pyrazole derivative for therapy of thrombocytopenia | SMITHKLINE BEECHAM CORPORATION | 2003-04-22 | — | — | US | claimed |
| EP-1223944-B1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2007-01-03 | — | — | EP | disclosed |
| US-6552008-B1 | Administering effective amount of a selected azo-pyrazole derivative for therapy of thrombocytopenia | SMITHKLINE BEECHAM CORPORATION | 2003-04-22 | — | — | US | disclosed |
| EP-1223944-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-1223944-A1 | THROMBOPOIETIN MIMETICS | SmithKline Beecham Corporation (US) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001021180-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-29 | — | — | WO | disclosed |