Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | ACTR2 | P61160 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 7/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204507 | 0.90 | MAPK14 (0.47) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL14185128 | 0.88 | MAPK14 (0.59) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL14185098 | 0.84 | MAPK14 (0.42) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL5201216 | 0.84 | MAPK14 (0.51) | MAPK14ALOX5ALDH1A1MAPT | |
| SCHEMBL20883157 | 0.82 | MAPK14 (0.47) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL14185145 | 0.80 | MAPK14 (0.51) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4503016 | 0.80 | MAPK14 (0.51) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL14185126 | 0.78 | MAPK14 (0.73) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL14294593 | 0.77 | MAPK14 (0.61) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL5203602 | 0.77 | MAPK14 (0.51) | MAPK14ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178983-B1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | SCIOS INC (US) | 2007-10-24 | — | — | EP | claimed |