Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1D | O15297 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | STAT6 | P42226 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537571 | 0.93 | PPM1D (0.46) | PPM1D | |
| SCHEMBL12543318 | 0.84 | PPM1D (0.44) | PPM1DMAPK1TP53NFKB1CYP2C19 | |
| SCHEMBL30720748 | 0.82 | PPM1D (0.41) | PPM1DMAPK1TP53NFKB1CYP2C19 | |
| SCHEMBL8901744 | 0.81 | PPM1D (0.38) | PPM1D | |
| SCHEMBL3178611 | 0.77 | PPM1D (0.45) | PPM1D | |
| SCHEMBL8539978 | 0.77 | PPM1D (0.45) | PPM1D | |
| SCHEMBL3622067 | 0.75 | PPM1D (0.41) | PPM1DMAPK1TP53NFKB1CYP2C19 | |
| SCHEMBL23704804 | 0.75 | PPM1D (0.37) | PPM1D | |
| SCHEMBL3568839 | 0.74 | PPM1D (0.37) | PPM1D | |
| SCHEMBL25497955 | 0.74 | PPM1D (0.36) | PPM1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603930-B1 | PROTEIN-BOUND DERIVATIVES OF PLATINUM COMPLEXES CONTAINING CYCLOBUTANE 1.1-DICARBOXYLLATE LIGANDS | KTB TUMORFORSCHUNGS GMBH (DE) | 2007-08-29 | — | — | EP | claimed |