Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.58 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | ACTR2 | P61160 | 1/20 | 0.43 |
| ▸ | MLNR | O43193 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201743 | 0.91 | MAPK14 (0.56) | MAPK14MLNRCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5204693 | 0.89 | MAPK14 (0.52) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL5205291 | 0.87 | MAPK14 (0.60) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL5205942 | 0.87 | MAPK14 (0.59) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL5202678 | 0.84 | MAPK14 (0.54) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL5202008 | 0.81 | MAPK14 (0.59) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL5202317 | 0.81 | MAPK14 (0.59) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL5201793 | 0.81 | MAPK14 (0.59) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL5203711 | 0.81 | MAPK14 (0.59) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL14454036 | 0.80 | MAPK14 (0.53) | MAPK14CYP2C9CYP2C19HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178983-B1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | SCIOS INC (US) | 2007-10-24 | — | — | EP | claimed |