SCHEMBL5205532

SCHEMBL5205532

CC(=O)N(CCCN(C(=O)c1ccc(-c2ccccc2)cc1)c1ccc(Cl)cc1Oc1cccc(CNC(=O)OC(C)(C)C)c1)c1ccccc1F

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSPO P30536 1/20 0.39
PTGES O14684 3/20 0.38
ALOX5 P09917 3/20 0.38
PPARG P37231 2/20 0.37
PPARD Q03181 2/20 0.37
PPARA Q07869 2/20 0.37
HDAC1 Q13547 1/20 0.37
LPAR1 Q92633 3/20 0.35
LPAR5 Q9H1C0 2/20 0.35
LTC4S Q16873 1/20 0.34
NAMPT P43490 2/20 0.33
EPAS1 Q99814 1/20 0.32
ROCK2 O75116 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
ROCK1 Q13464 1/20 0.32
MAPK14 Q16539 1/20 0.32
GLS O94925 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5205558 0.88 HDAC1 (0.42) TSPOPTGESALOX5PPARGPPARD
SCHEMBL5204846 0.88 HDAC1 (0.42) TSPOPTGESALOX5PPARGPPARD
SCHEMBL5205540 0.87 P2RX4 (0.37) TSPOPTGESALOX5PPARGPPARD
SCHEMBL5205723 0.87 HDAC1 (0.41) TSPOPTGESALOX5PPARGPPARD
SCHEMBL5201617 0.87 HDAC1 (0.44) TSPOPTGESALOX5PPARGPPARD
SCHEMBL5205622 0.87 PPARG (0.36) TSPOPTGESALOX5PPARGPPARD
SCHEMBL5204775 0.87 HDAC1 (0.39) TSPOPTGESALOX5PPARGPPARD
SCHEMBL5207637 0.85 HDAC1 (0.44) TSPOPTGESALOX5PPARGPPARD
SCHEMBL5205929 0.85 PPARG (0.40) TSPOPTGESALOX5PPARGPPARD
SCHEMBL5207965 0.85 PPARG (0.40) TSPOPTGESALOX5PPARGPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7160887-B1 Aromatic amine derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-01-09 US disclosed
EP-1123918-B1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME TAKEDA PHARMACEUTICAL (JP) 2005-03-09 EP disclosed
EP-1123918-A1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME Takeda Chemical Industries, Ltd. (JP) 2001-08-16 EP disclosed