SCHEMBL5205540

SCHEMBL5205540

CC(C)(C)OC(=O)NCc1cccc(Oc2cc(Cl)ccc2N(CCCNC(=O)Cc2ccccc2F)C(=O)c2ccc(-c3ccccc3)cc2)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX4 Q99571 1/20 0.37
PPARG P37231 1/20 0.36
PPARD Q03181 1/20 0.36
PPARA Q07869 1/20 0.36
HDAC1 Q13547 1/20 0.36
TSPO P30536 1/20 0.36
ALDH1A1 P00352 2/20 0.36
LMNA P02545 1/20 0.36
POLB P06746 1/20 0.36
HTT P42858 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
PTGES O14684 2/20 0.35
ALOX5 P09917 2/20 0.35
NAMPT P43490 2/20 0.34
AHCY P23526 1/20 0.34
GLS O94925 2/20 0.34
ACKR3 P25106 1/20 0.33
KDM4E B2RXH2 1/20 0.33
SUCNR1 Q9BXA5 1/20 0.33
SRC P12931 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5205622 0.93 PPARG (0.36) P2RX4PPARGPPARDPPARAHDAC1
SCHEMBL5204775 0.89 HDAC1 (0.39) PPARGPPARDPPARAHDAC1TSPO
Hydrochloric Acid SCHEMBL5206109 0.88 P2RX4 (0.39) P2RX4TSPOALDH1A1LMNAPOLB
SCHEMBL5205532 0.87 TSPO (0.39) PPARGPPARDPPARAHDAC1TSPO
SCHEMBL5203486 0.87 EPHX2 (0.35) PPARGPPARDPPARAHDAC1TSPO
SCHEMBL5204846 0.86 HDAC1 (0.42) PPARGPPARDPPARAHDAC1TSPO
SCHEMBL5205558 0.86 HDAC1 (0.42) PPARGPPARDPPARAHDAC1TSPO
SCHEMBL5205723 0.86 HDAC1 (0.41) PPARGPPARDPPARAHDAC1TSPO
SCHEMBL5201617 0.85 HDAC1 (0.44) PPARGPPARDPPARAHDAC1TSPO
SCHEMBL5207637 0.83 HDAC1 (0.44) PPARGPPARDPPARAHDAC1TSPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7160887-B1 Aromatic amine derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-01-09 US disclosed
EP-1123918-B1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME TAKEDA PHARMACEUTICAL (JP) 2005-03-09 EP disclosed
EP-1123918-A1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME Takeda Chemical Industries, Ltd. (JP) 2001-08-16 EP disclosed