Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CTSD | P07339 | 5/20 | 0.49 |
| ▸ | BACE1 | P56817 | 5/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3876015 | 1.00 | LMNA (0.54) | LMNAGAAHTTSMN1; SMN2NPSR1 | |
| Hydrochloric Acid SCHEMBL5220538 | 0.99 | LMNA (0.53) | LMNAGAAHTTSMN1; SMN2NPSR1 | |
| SCHEMBL4214871 | 0.91 | BCHE (0.61) | BCHECTSDBACE1DNM1 | |
| SCHEMBL165644 | 0.91 | BCHE (0.61) | BCHECTSDBACE1DNM1 | |
| Hydrochloric Acid SCHEMBL5219676 | 0.90 | CHRM2 (0.50) | LMNAGAAHTTSMN1; SMN2NPSR1 | |
| Hydrochloric Acid SCHEMBL6110582 | 0.90 | BCHE (0.60) | BCHECTSDBACE1DNM1 | |
| Hydrochloric Acid SCHEMBL5348922 | 0.90 | BCHE (0.60) | BCHECTSDBACE1DNM1 | |
| SCHEMBL3869254 | 0.87 | BCHE (0.48) | BCHECTSDBACE1DNM1TAAR1 | |
| Hydrochloric Acid SCHEMBL5223667 | 0.86 | BCHE (0.47) | BCHECTSDBACE1DNM1TAAR1 | |
| SCHEMBL3355576 | 0.84 | BACE1 (0.57) | CTSDBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551801-A4 | NOVEL GAMMA-LACTAMS AS BETA-SECRETASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2007-06-20 | — | — | EP | disclosed |
| EP-1551801-A1 | NOVEL GAMMA-LACTAMS AS BETA-SECRETASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004013098-A1 | NOVEL GAMMA-LACTAMS AS BETA-SECRETASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-02-12 | — | — | WO | disclosed |