SCHEMBL5206315

SCHEMBL5206315

Cc1ccc(-c2cccc(/C=C/C(=O)O)c2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 5/20 0.55
AKR1C4 P17516 4/20 0.55
AKR1C2 P52895 3/20 0.55
NPSR1 Q6W5P4 1/20 0.54
HDAC2 Q92769 2/20 0.52
HDAC8 Q9BY41 2/20 0.52
PIM2 Q9P1W9 1/20 0.52
AKR1C1 Q04828 1/20 0.52
HDAC3 O15379 1/20 0.52
TNKS O95271 1/20 0.52
HDAC4 P56524 1/20 0.52
HDAC1 Q13547 1/20 0.52
HCAR2 Q8TDS4 1/20 0.52
HDAC7 Q8WUI4 1/20 0.52
HDAC10 Q969S8 1/20 0.52
HDAC11 Q96DB2 1/20 0.52
TNKS2 Q9H2K2 1/20 0.52
HDAC6 Q9UBN7 1/20 0.52
HDAC9 Q9UKV0 1/20 0.52
HDAC5 Q9UQL6 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1510043 1.00 AKR1C3 (0.55) AKR1C3AKR1C4AKR1C2NPSR1HDAC2
SCHEMBL1510681 0.89 IP6K1 (0.59) NPSR1HDAC2HDAC8PIM2HDAC3
SCHEMBL414597 0.88 HDAC2 (0.67) NPSR1HDAC2HDAC8PIM2HDAC3
SCHEMBL30584137 0.88 HDAC2 (0.67) NPSR1HDAC2HDAC8PIM2HDAC3
SCHEMBL414598 0.88 HDAC2 (0.67) NPSR1HDAC2HDAC8PIM2HDAC3
SCHEMBL2338063 0.85 HDAC2 (0.70) NPSR1HDAC2HDAC8PIM2HDAC3
SCHEMBL2338070 0.85 HDAC2 (0.70) NPSR1HDAC2HDAC8PIM2HDAC3
SCHEMBL8265112 0.84 IP6K1 (0.57) AKR1C3AKR1C4AKR1C2NPSR1HDAC2
SCHEMBL1510042 0.84 NPSR1 (0.54) NPSR1HDAC2HDAC8PIM2HDAC3
SCHEMBL1510041 0.84 NPSR1 (0.54) NPSR1HDAC2HDAC8PIM2HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1040103-B1 ANILIDE DERIVATIVE, PRODUCTION AND USE THEREOF TAKEDA PHARMACEUTICAL (JP) 2007-03-14 EP disclosed
US-6413947-B1 Anilide derivative, production and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-07-02 US disclosed
US-6268354-B1 Pharmaceutical composition for antagonizing CCR5 comprising anilide derivative TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-07-31 US disclosed
US-6172061-B1 AIDS THERAPY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-01-09 US disclosed
US-6166006-A Anilide derivative, production and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-12-26 US disclosed
EP-1039899-A2 PHARMACEUTICAL COMPOSITION FOR ANTAGONIZING CCR5 COMPRISING ANILIDE DERIVATIVE Takeda Chemical Industries, Ltd. (JP) 2000-10-04 EP disclosed
EP-1040103-A1 ANILIDE DERIVATIVE, PRODUCTION AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2000-10-04 EP disclosed
WO-1999032100-A2 PHARMACEUTICAL COMPOSITION FOR ANTAGONIZING CCR5 COMPRISING ANILIDE DERIVATIVE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-07-01 WO disclosed
WO-1999032468-A1 ANILIDE DERIVATIVE, PRODUCTION AND USE THEREOF TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-07-01 WO disclosed