SCHEMBL414597

SCHEMBL414597

O=C(O)/C=C/c1cccc(-c2ccccc2)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 3/20 0.67
HDAC8 Q9BY41 3/20 0.67
HDAC3 O15379 2/20 0.67
HDAC4 P56524 2/20 0.67
HDAC1 Q13547 2/20 0.67
HDAC7 Q8WUI4 2/20 0.67
HDAC10 Q969S8 2/20 0.67
HDAC11 Q96DB2 2/20 0.67
HDAC6 Q9UBN7 2/20 0.67
HDAC9 Q9UKV0 2/20 0.67
HDAC5 Q9UQL6 2/20 0.67
TNKS O95271 1/20 0.67
HCAR2 Q8TDS4 1/20 0.67
TNKS2 Q9H2K2 1/20 0.67
NPSR1 Q6W5P4 1/20 0.62
PIM2 Q9P1W9 1/20 0.59
PKM P14618 2/20 0.55
PLAAT3 P53816 1/20 0.55
PLAAT5 Q96KN8 1/20 0.55
PLAAT2 Q9NWW9 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL414598 1.00 HDAC2 (0.67) HDAC2HDAC8HDAC3HDAC4HDAC1
SCHEMBL30584137 1.00 HDAC2 (0.67) HDAC2HDAC8HDAC3HDAC4HDAC1
SCHEMBL2338070 0.90 HDAC2 (0.70) HDAC2HDAC8HDAC3HDAC4HDAC1
SCHEMBL2338063 0.90 HDAC2 (0.70) HDAC2HDAC8HDAC3HDAC4HDAC1
SCHEMBL5206315 0.88 AKR1C3 (0.55) HDAC2HDAC8HDAC3HDAC4HDAC1
SCHEMBL1510500 0.88 NPSR1 (0.54) HDAC2HDAC8HDAC3HDAC4HDAC1
SCHEMBL1510042 0.88 NPSR1 (0.54) HDAC2HDAC8HDAC3HDAC4HDAC1
SCHEMBL1510043 0.88 AKR1C3 (0.55) HDAC2HDAC8HDAC3HDAC4HDAC1
SCHEMBL1510041 0.88 NPSR1 (0.54) HDAC2HDAC8HDAC3HDAC4HDAC1
SCHEMBL31560039 0.88 RELA (0.66) HDAC2HDAC8HDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559743-B1 Infra-red radiation absorption articles and method of manufacturing thereof SABIC INNOVATIVE PLASTICS IP (NL) 2009-02-18 EP claimed
US-7399571-B2 Multilayered articles and method of manufacture thereof GENERAL ELECTRIC COMPANY (US) 2008-07-15 US claimed
US-20060251996-A1 Multilayered articles and method of manufacture thereof SABIC GLOBAL TECHNOLOGIES IP B.V. (NL) 2006-11-09 US claimed
WO-2005075550-A1 INFRA-RED RADIATION ABSORPTION ARTICLES AND METHOD OF MANUFACTURE THEREOF GENERAL ELECTRIC COMPANY (US) 2005-08-18 WO claimed
EP-1559743-A1 Infra-red radiation absorption articles and method of manufacturing thereof GENERAL ELECTRIC COMPANY (US) 2005-08-03 EP claimed
US-20050165148-A1 Infra-red radiation absorption articles and method of manufacture thereof SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2005-07-28 US claimed
US-20050095433-A1 Multilayered articles and method of manufacture thereof SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2005-05-05 US claimed
WO-2005037815-A1 A MANUFACTURING PROCESS OF ISOFLAVAN OR ISOFLAVENE DERIVATIVES BICBIO CO., LTD. (KR) 2005-04-28 WO claimed
EP-3645598-B1 ADDITIVE MANUFACTURING METHOD COMPRISING A THERMOPLASTIC STRUCTURAL MATERIAL WHICH IS CROSSLINKABLE WITH RADICALS STRATASYS INC (US) 2024-06-19 EP disclosed
CN-117402123-A Alpha, beta-unsaturated amide compounds, preparation method, pharmaceutical composition and application thereof 中国科学院上海药物研究所 2024-01-16 CN disclosed
CN-112204018-B Acrylic compound, preparation method, pharmaceutical composition and application thereof 中国科学院上海药物研究所 2023-08-29 CN disclosed
CN-112204018-A Acrylic acid compounds, preparation method thereof, pharmaceutical composition and application 中国科学院上海药物研究所 2021-01-08 CN disclosed
EP-1724110-B1 Multilayered articles and method of manufacture thereof SABIC GLOBAL TECHNOLOGIES BV (NL) 2019-08-21 EP disclosed
EP-2632707-B1 MULTILAYERED CARBONATE SHEETS TRINSEO EUROPE GMBH (CH) 2019-04-10 EP disclosed
EP-0395446-B1 N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists SANKYO CO (JP) 1995-03-01 EP disclosed
US-5369106-A N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists SANKYO COMPANY, LIMITED (JP) 1994-11-29 US disclosed
US-5192766-A Platelet activating factor antagonist SANKYO COMPANY, LIMITED (JP) 1993-03-09 US disclosed
EP-0395446-A2 N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists Sankyo Company Limited (JP) 1990-10-31 EP disclosed
US-4368945-A Infrared reflecting laminated glass for automobile ASAHI GLASS COMPANY, LTD. (JP) 1983-01-18 US disclosed
US-4267084-A MOLDING MATERIALS COMPRISING AN ALKYL MERCAPTAN-MODIFIED VINYL CHLORIDE POLYMER AND ANOTHER VINYL CHLORIDE POLYMER, HEAT RESISTANCE; PROCESS CONTROL TOKUYAMA SODA KABUSHIKI KAISHA (JP) 1981-05-12 US disclosed