Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 12/20 | 0.44 |
| ▸ | PPARG | P37231 | 11/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2917013 | 0.94 | TP53 (0.46) | PPARAPPARGTP53MAPTFFAR1 | |
| SCHEMBL5278398 | 0.90 | PPARG (0.50) | PPARAPPARGTP53MAPTFFAR1 | |
| SCHEMBL2523255 | 0.90 | PPARA (0.45) | PPARAPPARGTP53MAPTFFAR1 | |
| SCHEMBL2523252 | 0.90 | PPARA (0.45) | PPARAPPARGTP53MAPTFFAR1 | |
| SCHEMBL5213251 | 0.88 | TP53 (0.49) | PPARAPPARGTP53MAPTFFAR1 | |
| SCHEMBL5299157 | 0.88 | MAPT (0.44) | PPARAPPARGTP53MAPTALDH1A1 | |
| SCHEMBL5210899 | 0.84 | PPARA (0.49) | PPARAPPARGTP53MAPTFFAR1 | |
| SCHEMBL5213073 | 0.83 | PPARG (0.54) | PPARAPPARG | |
| SCHEMBL14071895 | 0.83 | TP53 (0.47) | PPARAPPARGTP53MAPTFFAR1 | |
| SCHEMBL181098 | 0.83 | TP53 (0.47) | PPARAPPARGTP53MAPTFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448523-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | NOVARTIS AG (CH) | 2007-08-22 | — | — | EP | claimed |