Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3235999 | 0.92 | KDM4E (0.58) | TAAR1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL12521121 | 0.83 | SCN8A (0.54) | TAAR1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL10562876 | 0.83 | TAAR1 (0.56) | TAAR1KDM4ETDP1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10560147 | 0.82 | TAAR1 (0.54) | TAAR1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL18161368 | 0.81 | TAAR1 (0.65) | TAAR1KDM4EHDAC1HDAC8SIGMAR1 | |
| SCHEMBL5175432 | 0.80 | KDM4E (0.49) | TAAR1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL5176778 | 0.80 | KDM4E (0.49) | TAAR1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL5175308 | 0.80 | KDM4E (0.55) | TAAR1KDM4ETDP1MEN1KMT2A | |
| SCHEMBL5177801 | 0.80 | ADRA2C (0.52) | TAAR1KDM4EMEN1KMT2ASIGMAR1 | |
| SCHEMBL28246680 | 0.79 | TAAR1 (0.55) | TAAR1KDM4ETDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776338-A1 | INDOLE, INDAZOLE OR INDOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006013048-A1 | INDOLE, INDAZOLE OR INDOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-02-09 | — | — | WO | disclosed |