Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206407 | 1.00 | MAPT (0.51) | MAPTHRH3ALDH1A1MAPK1POLB | |
| SCHEMBL31042547 | 0.82 | MAPT (0.54) | MAPTHRH3ALDH1A1POLBCYP2C9 | |
| SCHEMBL19221745 | 0.81 | MAPT (0.53) | MAPTHRH3ALDH1A1MAPK1POLB | |
| SCHEMBL19221744 | 0.81 | MAPT (0.53) | MAPTHRH3ALDH1A1MAPK1POLB | |
| SCHEMBL1751383 | 0.80 | MAPT (0.52) | MAPTHRH3ALDH1A1MAPK1POLB | |
| SCHEMBL1751385 | 0.80 | MAPT (0.52) | MAPTHRH3ALDH1A1MAPK1POLB | |
| SCHEMBL28417404 | 0.79 | NPC1 (0.48) | MAPTHRH3ALDH1A1MAPK1KMT2A | |
| SCHEMBL6730754 | 0.78 | MAPT (0.50) | MAPTHRH3ALDH1A1MAPK1POLB | |
| SCHEMBL25845507 | 0.78 | MAPT (0.60) | MAPTHRH3ALDH1A1POLBCYP2C9 | |
| SCHEMBL27832 | 0.77 | SIRT6 (0.59) | MAPTHRH3ALDH1A1POLBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |