Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 1/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205838 | 0.89 | AKR1C2 (0.61) | AKR1C2HDAC1MAPTMTNR1AMTNR1B | |
| SCHEMBL5214528 | 0.89 | AKR1C2 (0.61) | AKR1C2HDAC1MAPTMTNR1AMTNR1B | |
| SCHEMBL5209238 | 0.87 | AKR1C2 (0.59) | AKR1C2HDAC1MAPTMTNR1AMTNR1B | |
| SCHEMBL5209948 | 0.87 | MAPT (0.62) | AKR1C2HDAC1MAPTMTNR1AMTNR1B | |
| SCHEMBL5208935 | 0.87 | MEN1 (0.62) | AKR1C2HDAC1MAPTMTNR1AMTNR1B | |
| SCHEMBL5208570 | 0.87 | AKR1C2 (0.59) | AKR1C2HDAC1MAPTMTNR1AMTNR1B | |
| SCHEMBL5213791 | 0.86 | POLB (0.52) | AKR1C2HCAR2MAPTSMN1; SMN2POLB | |
| SCHEMBL5211125 | 0.86 | AKR1C2 (0.58) | AKR1C2HDAC1MAPTMTNR1AMTNR1B | |
| SCHEMBL5210270 | 0.86 | AKR1C2 (0.60) | AKR1C2HDAC1MAPTMTNR1AMTNR1B | |
| SCHEMBL5210657 | 0.85 | AKR1C2 (0.59) | AKR1C2HDAC1MAPTMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288564-B2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 2007-10-30 | — | — | US | claimed |
| US-7288564-B2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 2007-10-30 | — | — | US | disclosed |
| EP-1343757-B1 | INDOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 2007-02-14 | — | — | EP | disclosed |
| US-20040092569-A1 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 2004-05-13 | — | — | US | disclosed |
| EP-1343757-A1 | INDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002050031-A1 | INDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2002-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040092569-A1 | Indole derivatives | PTGER4, PTGER1, TRPV4 | AKR1C2 1632/4885HDAC1 1653/4885HCAR2 307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.