Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204735 | 0.91 | MAOB (0.50) | MAOBSMN1; SMN2 | |
| SCHEMBL1419820 | 0.85 | MEN1 (0.53) | MAOBRAB9ANPC1FFAR1BCHE | |
| SCHEMBL5207565 | 0.85 | TYR (0.48) | MAOBRAB9ANPC1MAPTMAPK1 | |
| SCHEMBL3955351 | 0.82 | MEN1 (0.51) | RAB9ANPC1TDP1MAPTMAPK1 | |
| SCHEMBL4731187 | 0.81 | TYR (0.49) | RAB9ANPC1MAPTMAPK1BCHE | |
| SCHEMBL11558512 | 0.79 | ACP3 (0.44) | MAOBRAB9ANPC1MAPTNPSR1 | |
| SCHEMBL5202082 | 0.78 | TYR (0.47) | RAB9ANPC1MAPTMAPK1BCHE | |
| SCHEMBL8505924 | 0.76 | LMNA (0.53) | MAOBRAB9AMAPTBCHESMN1; SMN2 | |
| SCHEMBL8505922 | 0.76 | LMNA (0.53) | MAOBRAB9AMAPTBCHESMN1; SMN2 | |
| SCHEMBL2844054 | 0.76 | LMNA (0.53) | MAOBRAB9AMAPTBCHESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802599-A2 | HETEROARYL-CONTAINING ISOFLAVONES AS AROMATASE INHIBITORS | The Ohio State University Research Foundation (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2007001348-A2 | HETEROARYL-CONTAINING ISOFLAVONES AS AROMATASE INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2007-01-04 | — | — | WO | disclosed |