Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5211479 | 1.00 | BCHE (0.67) | BCHEKDM4EMAPTGAAHTT | |
| Tetrahydropapaverine SCHEMBL30298903 | 0.92 | BCHE (0.79) | BCHEKDM4EMAPTGAAHTT | |
| Tetrahydropapaverine SCHEMBL29375914 | 0.92 | BCHE (0.79) | BCHEKDM4EMAPTGAAHTT | |
| Tetrahydropapaverine SCHEMBL30298880 | 0.92 | BCHE (0.79) | BCHEKDM4EMAPTGAAHTT | |
| Tetrahydropapaverine SCHEMBL251076 | 0.92 | BCHE (0.79) | BCHEKDM4EMAPTGAAHTT | |
| Tetrahydropapaverine SCHEMBL31612469 | 0.92 | BCHE (0.79) | BCHEKDM4EMAPTGAAHTT | |
| Tetrahydropapaverine SCHEMBL6398843 | 0.92 | BCHE (0.79) | BCHEKDM4EMAPTGAAHTT | |
| Tetrahydropapaverine SCHEMBL1076975 | 0.92 | BCHE (0.79) | BCHEKDM4EMAPTGAAHTT | |
| Tetrahydropapaverine SCHEMBL30441145 | 0.92 | BCHE (0.79) | BCHEKDM4EMAPTGAAHTT | |
| Tetrahydropapaverine SCHEMBL6382627 | 0.91 | BCHE (0.77) | BCHEKDM4EMAPTGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347967-B1 | NOVEL BENZAZEPINES AND RELATED HETEROCYCLIC DERIVATIVES WHICH ARE USEFUL AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2007-12-19 | — | — | EP | disclosed |
| US-7192950-B2 | Benzazepines and related heterocyclic derivatives which are useful as orexin receptor antagonists | ACTELION PHARMACEUTICALS, LTD. (CH) | 2007-03-20 | — | — | US | disclosed |
| US-20040058912-A1 | Novel benzazepines and related heterocyclic derivatives which are useful as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-03-25 | — | — | US | disclosed |
| EP-1347967-A1 | NOVEL BENZAZEPINES AND RELATED HETEROCYCLIC DERIVATIVES WHICH ARE USEFUL AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002051838-A1 | NOVEL BENZAZEPINES AND RELATED HETEROCYCLIC DERIVATIVES WHICH ARE USEFUL AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2002-07-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058912-A1 | Novel benzazepines and related heterocyclic derivatives which are useful as orexin receptor antagonists | HCRTR2, HCRTR1, OXTR | BCHE 548/4885KDM4E 1024/4885MAPT 1575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.