Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 5/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 5/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KCNQ5 | Q9NR82 | 2/20 | 0.38 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5757380 | 0.85 | PTGS2 (0.50) | PTGS2SMN1; SMN2CA12CA1CA2 | |
| SCHEMBL5239038 | 0.76 | TSHR (0.49) | CA12CA1CA9SLC6A4KDM4E | |
| SCHEMBL31388364 | 0.75 | ERN1 (0.43) | PTGDR2SMN1; SMN2CA12CA1CA2 | |
| SCHEMBL5207689 | 0.74 | CA12 (0.63) | SMN1; SMN2CA12CA1CA2CA7 | |
| SCHEMBL31388318 | 0.74 | CA12 (0.44) | PTGDR2SMN1; SMN2CA12CA1CA2 | |
| SCHEMBL28745794 | 0.74 | HPGD (0.40) | PTGS2SMN1; SMN2CA12CA1CA2 | |
| SCHEMBL28623953 | 0.73 | CA12 (0.40) | PTGDR2SMN1; SMN2CA12CA1CA2 | |
| SCHEMBL15068183 | 0.73 | PTGS2 (0.55) | PTGS2PTGDR2SMN1; SMN2BRD4SLC6A4 | |
| SCHEMBL21190753 | 0.73 | EPAS1 (0.60) | PTGS2PTGDR2SMN1; SMN2BRD4PTGS1 | |
| SCHEMBL15067760 | 0.73 | SMN1; SMN2 (0.66) | PTGS2SMN1; SMN2BRD4PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040102-B1 | ARYLTHIAZOLIDINEDIONE DERIVATIVES | MERCK & CO INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-1040102-A4 | ARYLTHIAZOLIDINEDIONE DERIVATIVES | MERCK & CO INC (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-1040102-A1 | ARYLTHIAZOLIDINEDIONE DERIVATIVES | Merck & Co., Inc. (US) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999032465-A1 | ARYLTHIAZOLIDINEDIONE DERIVATIVES | MERCK & CO., INC. (US) | 1999-07-01 | — | — | WO | disclosed |