Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.45 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.45 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3986594 | 0.87 | NAMPT (0.51) | NAMPTGPR119NPC1RAB9ADRD2 | |
| SCHEMBL14587425 | 0.87 | GPR119 (0.51) | NAMPTGPR119NPC1POLBRAB9A | |
| SCHEMBL3985434 | 0.86 | NPC1 (0.52) | NAMPTNPC1POLBRAB9ADRD2 | |
| SCHEMBL5659857 | 0.83 | NAMPT (0.54) | NAMPTGPR119NPC1RAB9ADRD2 | |
| SCHEMBL10127693 | 0.82 | NAMPT (0.52) | NAMPTGPR119USP30ALOX12STS | |
| SCHEMBL3988080 | 0.81 | GPR119 (0.46) | NAMPTGPR119DRD2ALOX12 | |
| SCHEMBL3811908 | 0.81 | GPR119 (0.46) | NAMPTGPR119STSLMNATHRB | |
| SCHEMBL2878255 | 0.80 | NAMPT (0.57) | NAMPTGPR119NPC1RAB9ADRD2 | |
| SCHEMBL5663251 | 0.79 | PTPN2 (0.62) | NAMPTGPR119NPC1RAB9AALOX12 | |
| SCHEMBL22315798 | 0.79 | EPHX1 (0.59) | GPR119NPC1RAB9ASTS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556351-A4 | SECONDARY AMINO ANILINIC PIPERIDINES AS MCH1 ANTAGONISTS AND USES THEREOF | LUNDBECK & CO AS H (DK) | 2007-07-25 | — | — | EP | disclosed |
| EP-1556351-A1 | SECONDARY AMINO ANILINIC PIPERIDINES AS MCH1 ANTAGONISTS AND USES THEREOF | H. Lundbeck A/S (DK) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004005257-A1 | SECONDARY AMINO ANILINIC PIPERIDINES AS MCH1 ANTAGONISTS AND USES THEREOF | H. LUNDBECK A/S (DK) | 2004-01-15 | — | — | WO | disclosed |