Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5210894 | 0.99 | HRH3 (0.54) | HRH3KDM4EABL1LMNACYP3A4 | |
| SCHEMBL3967944 | 0.86 | KDM4E (0.58) | HRH3KDM4EABL1LMNACYP3A4 | |
| SCHEMBL27728031 | 0.84 | KDM4E (0.56) | HRH3KDM4EABL1LMNACYP3A4 | |
| Hydrochloric Acid SCHEMBL27620712 | 0.82 | HRH3 (0.61) | HRH3KDM4EABL1LMNACYP3A4 | |
| SCHEMBL5208071 | 0.81 | HRH3 (0.45) | HRH3 | |
| SCHEMBL4936071 | 0.81 | KDM4E (0.51) | HRH3KDM4EABL1LMNACYP3A4 | |
| SCHEMBL5212275 | 0.81 | HRH3 (0.70) | HRH3KDM4EABL1LMNACYP3A4 | |
| Hydrochloric Acid SCHEMBL5210095 | 0.81 | HRH3 (0.44) | HRH3 | |
| SCHEMBL3860897 | 0.80 | KDM4E (0.65) | HRH3KDM4EABL1LMNACYP2C9 | |
| Hydrochloric Acid SCHEMBL5216496 | 0.80 | HRH3 (0.69) | HRH3KDM4EABL1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646620-B1 | SUBSTITUTED PIPERIDINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LTD (GB) | 2007-08-15 | — | — | EP | claimed |