Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5058463 | 0.96 | ABCB1 (0.49) | ABCB1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL5062407 | 0.82 | ABCB1 (0.53) | ABCB1SMN1; SMN2HPGD | |
| SCHEMBL9714501 | 0.82 | ABCB1 (0.60) | ABCB1 | |
| SCHEMBL9903862 | 0.81 | HPGD (0.63) | ABCB1SMN1; SMN2HPGD | |
| SCHEMBL5209743 | 0.80 | ABCB1 (0.57) | ABCB1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL5064387 | 0.79 | HPGD (0.63) | ABCB1SMN1; SMN2HPGD | |
| SCHEMBL5053794 | 0.79 | HPGD (0.43) | ABCB1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL5062538 | 0.78 | ABCB1 (0.55) | ABCB1 | |
| SCHEMBL5056937 | 0.77 | CYP1A2 (0.48) | SMN1; SMN2HPGD | |
| SCHEMBL5056941 | 0.77 | HPGD (0.56) | ABCB1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601642-A4 | BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX | RHEOGENE INC (US) | 2007-04-11 | — | — | EP | claimed |
| EP-1601642-A2 | BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX | RheoGene, Inc. (US) | 2005-12-07 | — | — | EP | claimed |
| WO-2004078924-A2 | BIOAVAILABLE DIACYLHYDRAZINE LIGANDS FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX | RHEOGENE, INC. (US) | 2004-09-16 | — | — | WO | claimed |
| EP-2460786-A1 | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex | Intrexon Corporation (US) | 2012-06-06 | — | — | EP | disclosed |